MESNA es incompatible con el cisplatino y la mostaza nitrogenada. PRECAUCIONES EN RELACIÓN CON EFECTOS DE CARCINOGÉNESIS, MUTAGÉNESIS. Aumentan sus efectos tóxicos con: Furosemida, cisplatino, indometacina, Con aminoglucósidos, anfotericina B, cisplatino y vancomicina, aumenta el riesgo. que no habían recibido quimioterapia previa y que recibieron quimioterapia altamente emetogénica (cisplatino ≥ 70 mg/m² o ciclofosfamida > 1, mg/m²).
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