ATGAM is the purified, concentrated and sterile gamma globulin, primarily During processing, the drug is adsorbed with human erythrocyte stroma and with . Globulin [Equine] Sterile Solution. Brand Name Equivalent: Atgam® Product Insert “Preservative Information” indicates that this product does not contain. Brand names: Atgam, Lymphoglobuline, Thymogam up ↑ Antithymocyte globulin, horse ATG (Atgam) package insert (locally hosted backup).
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The maximum tolerated dose of ATGAM Sterile Solution would be expected to vary from patient to patient due to the biological nature of the product. The range for half-life was 1.
Kidney enlargement, Kidney rupture, Renal failure acute.
Previously masked reactions to ATGAM may appear when the dose of corticosteroids and other immunosuppressants is being reduced. Use only if the potential benefit justifies the risk. Apnea, Cough, Epistaxis, Oropharyngeal pain. Dyskinesia, Syncope, Tremor Cardiac disorders: It is also not known whether ATGAM can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
Transplant Proc ; 13 1: Skin Testing To identify those at greatest risk of systemic packabe, skin testing potential recipients is strongly recommended before commencing treatment. Adverse reactions in both groups were comparable and included rash, chills, gastrointestinal disturbances, and joint pain during ATGAM infusion, as well as symptoms of serum sickness in all patients. The renal transplantation and aplastic anemia patients received a similar dosing regimen, and these data were pooled to obtain the frequencies listed in Tables 1 and 2 paxkage.
ATGAM is used with concomitant immunosuppressants.
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Hyperhidrosis Musculoskeletal and connective tissue disorders: ATGAM packaeg a transparent to slightly opalescent aqueous protein solution. While the etiology of this toxicity is uncertain, it may be attributed to hemolytic anemia due to cross-reactivity of ATGAM to a monkey red blood antigen.
Always keep appropriate resuscitation equipment at atgan patient’s bedside while ATGAM is being administered.
A conservative, conventional approach would first employ epicutaneous prick testing with undiluted ATGAM. Hepatitis viral, Localized infection, Systemic infection Blood and lymphatic system disorders: The effect of ATGAM when administered in conjunction with standard therapy at the time of diagnosis of the first rejection episode was studied under two different protocols with cadaveric and living related renal transplant patients.
There was no difference in the patient survival rate between the two treatment groups. Concomitant administration of ATGAM with live virus vaccines carries a potential of uncontrolled viral replication in the immunosuppressed patient.
If the subject does not show a wheal ten minutes after pricking, proceed to intradermal testing with 0.
Antithymocyte globulin, horse ATG (Atgam)
ATGAM has been administered safely to a small number atgwm pediatric renal allograft recipients and pediatric aplastic anemia patients at dosage levels comparable to those in adults. Use high-flow veins to minimize the occurrence of phlebitis and thrombosis. There are no adequate and well-controlled studies in pregnant women.
The most clinically significant adverse reactions are anaphylaxis, infection, thrombocytopenia, pakage, arthralgia, edema, bradycardia, and abnormal renal and liver function tests. Reversal of acute renal allograft rejection with adjunctive ATG therapy.
Select the dose for an elderly patient with caution, starting at the low end of the dosage range [see Use in Specific Populations 8. Deep vein thrombosis, Vasculitis Respiratory, thoracic and mediastinal disorders: A randomized double-blind, placebo prospective, controlled study was conducted to compare the safety and efficacy of ATGAM and androgen oxymetholone; OXY immunosuppressive therapy with the combination of ATGAM, androgen OXY and an infusion of HLA mismatched bone marrow in patients with severe aplastic anemia who were not candidates for bone marrow transplantation.
Infusion site erythema, Infusion site swelling, Pain. Flank pain, Ineert rigidity, Myalgia, Pain in extremity. Effects of antithymocyte globulin on cytomegalovirus infection in renal transplant recipients. Due to the small sample size, the difference between the ATGAM group and the control group in functional graft survival rate did not achieve statistical significance.
Results from randomized controlled trials in patients with first acute renal allograft rejection episodes refractory to inssert steroid therapy have demonstrated that ATGAM, when administered in conjunction with standard therapy, yields efficacy results superior to those of standard therapy alone.
Therefore, this toxicity is not considered relevant to human fetal development. Confusional state, Disorientation Nervous system disorders: For storage conditions of diluted solution, see Dosage and Administration 2.
Antithymocyte globulin, horse ATG (Atgam) | – A Hematology Oncology Wiki
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Pediatric Nephrol ; 5: ATGAM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
In this patient, the administration of ATGAM was not associated with any signs of acute intoxication or late sequelae.